ea0025oc3.5 | Pituitary and thyroid | SFEBES2011
Burrows Natalie
, Babur Muhammad
, Resch Julia
, Ridsdale Sophie
, Williams Joseph
, Brabant Georg
, Williams Kaye
The transcription factor HIF-1α regulates hypoxia-mediated gene expression which promotes tumour growth, metastasis and desensitisation to chemo-and radiotherapy. HIF-1 is functional in a range of thyroid-carcinoma cells and is regulated by hypoxia and the PI3K and MAPK-signalling pathways.We aimed to determine if HIF-1 and PI3K were important in the development of a metastatic phenotype and play a role in desensitisation to radiotherapy in thyroid ...